Power and Sample Size for RNA-Seq Data

PSS calculations for omics data require knowledge of the complex data generating procedures, as well as statistical concepts such as multiple testing, and generalized linear models specific to the type of data generated. This seminar will give a cursory introduction to these concepts and provide examples for calculating sample size and power for bulk RNA-seq experiments with biological replicates. Single-cell RNA-seq will not be the focus but we will briefly touch on considerations for these studies. Recommended background: This seminar assumes knowledge of basic statistical power concepts (power, sample size, effect size, level, Type I & II errors), which are covered in the introductory seminar in this series, Power and Sample Size 101. Slides are available at https://www.ohsu.edu/sites/default/files/2023-11/Power%20and%20Sample%20Size%20for%20RNA-seq%20Experiments.pdf

Intermediate

Free