Training Program Title

Unit 2: Evidence Generation Part 1: Comparative Effectiveness Trials Part 2: Assessing Pharmacogenetic Information in Clinical Trials

Contributor

Tufts CTSI

Competency Keywords

false

Public

yes

Cost to Access

no

Competency Domains

Scientific Concepts and Research Design

Learning Objectives

Identify the need for comparative effectiveness trials, even for drug therapies where "proof of efficacy" is already required prior to approval Explain the differences between pragmatic/effectiveness trials and explanatory/efficacy trials List the strengths and limitations of pragmatic versus explanatory designs State the strengths and limitations of various types of outcome measures, including surrogate versus clinical outcomes Explain the difference between prognostic and predictive genetic markers Identify the pros and cons of alternative research designs for assessing pharmacogenetic (predictive) effects Discuss “repurposed” randomized trials for assessing pharmacogenetic effects Define empirical data

Delivery Method

Online

Target Learners

Principal Investigators

Learning Level

Fundamental

Associated Assessment

no

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